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You should not use biaxin if you have a life-threatening heart rhythm disorder, a history of long qt syndrome, low levels of potassium in your blood, if you have ever had jaundice or liver problems caused by taking biaxin, or if you have liver or kidney disease and are also taking colchicine.
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Combining these two drugs may lead to fatal colchicine toxicity, particularly in patients with renal insufficiency.
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Myopathy rhabodomyolysis with acute renal failure and or myopathy reported; monitor patient closely dose adjustment required when coadministered with niacin, amiodarone, verapamil, diltiazem, amlodipine, and ranolazine predisposing factors for myopathy include advanced age 65 years , uncontrolled hypothyroidism, and renal impairment increased risk for myopathy in chinese patients coadministered niacin 1 g day; they should not receive simvastatin 80 mg coadministered with lipid-modifying doses of niacin-containing products withhold or levitra medication discontinue if myopathy, renal failure, or transaminase levels 3x uln develop risk of myopathy is greater in patients taking simvastatin 80 mg day, especially in the 1st year of treatment rare reports of immune-mediated necrotizing myopathy imnm , characterized by increased serum creatine kinase that persists despite discontinuing statin risk for myopathy increased when coadministered with other lipid-lowering drugs other fibrates, 1 g day of niacin, or, for patients with hofh, lomitapide , colchicine, amiodarone, dronedarone, verapamil, diltiazem, amlodipine, or ranolazine see contraindications for list of drugs contraindicated because of increased risk for myopathy when coadministered with simvastatin see adult dosing for dose limitations and modifications.
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